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Ozone Therapy Research References

Ozone therapy: A clinical review. Journal of Natural Science, Biology, and Medicine. 2011;2(1):66-70. doi:10.4103/09769668.82319.

Mechanisms of Action Involved in Ozone Therapy: Is healing induced via a mild oxidative stress? Medical Gas Research. 2011;1:29. doi:10.1186/2045-9912-1 29.

Bocci VA. Scientific and medical aspects of ozone therapy. State of the art.Arch Med Res. 2006 May;37(4):425-35. Review. PubMed PMID: 16624639


harmacology And Nutrition Intervention in the Treatment of Disease. Chapter 5: General Aspects of Ozone Therapy. Ruhi Cakir.

Prolozone-Regenerating Joints and Eliminating Pain. Frank Shallenberger, Md. J of Prolotherapy. 2011;3(2):630-638


Mechanisms of Actions & EffectsStudies on the biological effects of ozone: 7. Generation of reactive oxygen species (ROS) after exposure of human blood to ozone. J Biol Regul Homeost Agents. 1998 Jul-Sep;12(3):67-75. PubMed PMID: 9795834.

Studies on the biological effects of ozone: 8. Effects on the total antioxidant status and on interleukin-8 production. Mediators of Inflammation. 1998;7(5):313-317.

Effects of ozone on isolated peripheral blood mononuclearcells. Toxicol In Vitro. 2005 Feb;19(1):55-61. PubMed PMID: 15582356.


Intraarticular ozone therapy for pain control in osteoarthritis of the knee. [cited in 2010]. .

The Effect of Ozone Therapy for Lumbar Herniated Disc. [cited in 2010]. Available from:

Martínez-Sánchez G, Al-Dalain SM, Menéndez S, Re L, Giuliani A, Candelario-Jalil E, et al. Therapeutic efficacy of ozone in patients with diabetic foot. Eur J Pharmacol. 2005;523:151–61. [PubMed]

Carpendale MT, Freeberg JK. Ozone inactivates HIV at noncytotoxic concentrations. Anitiviral Res.1991;16:281–92. [PubMed]

Bocci V. Ozonization of blood for the therapy of viral diseases and immunodeficiencies: A hypothesis. Med Hypothesis. 1992;39:30–4. [PubMed]

Sharma M, Hudson JB. Ozone gas is an effective and practical antibacterial agent. Am J Infect Control.2008;36:559–63. [PubMed]

Molinari F, Simonetti V, Franzini M, Pandolfi S, Vaiano F, Valdenassi L,Liboni W. Ozone autohemotherapy induces long-term cerebral metabolic changes in multiple sclerosis patients. Int J Immunopathol Pharmacol. 2014 Jul-Sep;27(3):379-89. PubMed PMID: 25280029.

Neimark AI, Nepomnyashchikh LM, Lushnikova EL, Bakarev MA, Abdullaev NA, Sizov KA. Microcirculation and structural reorganization of the bladder mucosa in chronic cystitis under conditions of ozone therapy. Bull Exp Biol Med. 2014 Jan;156(3):399-405.

Zaky S, Kamel SE, Hassan MS, Sallam NA, Shahata MA, Helal SR, Mahmoud H.Preliminary results of ozone therapy as a possible treatment for patients with chronic hepatitis C. J Altern Complement Med. 2011 Mar;17(3):259-63. doi:10.1089/acm.2010.0016. PubMed PMID: 21417811.

Biedunkiewicz B, Tylicki L, Nieweglowski T, Burakowski S, Rutkowski B.Clinical efficacy of ozonated autohemotherapy in hemodialyzed patients with intermittent claudication: an oxygen-controlled study. Int J Artif Organs. 2004 Jan;27(1):29-34. PubMed PMID: 14984181.

Wu X, Li Z, Liu X, Peng H, Huang Y, Luo G, Peng K. Major ozonated autohemotherapy promotes the recovery of upper limb motor function in patients with acute cerebral infarction. Neural Regen Res. 2013 Feb 15;8(5):461-8. PubMed PMID: 25206688;

Kim HS, Noh SU, Han YW, Kim KM, Kang H, Kim HO, Park YM. Therapeutic effects of topical application of ozone on acute cutaneous wound healing. J Korean MedSci. 2009 Jun;24(3):368-74. doi: 10.3346/jkms.2009.24.3.368.

Dharmavaram AT, Reddy RS, Nallakunta R. “Ozone” – the new NEMESIS of cankersore. J Clin Diagn Res. 2015 Mar;9(3):ZC01-4. doi: 10.7860/JCDR/2015/11911.5617. VERA VIDAL, Vivian et al . Effectiveness of the ozone therapy in dry macular degeneration associated with the age.

Santiago de Cuba, v.15, n.6, jun. 2011 . Riva Sanseverino E, Meduri RA, Pizzino A, Prantera M, Martini E.

Effects of oxygen-ozone therapy on age-related degenerative retinal maculopathy. 

Panminerva Med. 1990 Apr-Jun;32(2):77-84.Borrelli E, Diadori A, Zalaffi A, Bocci V. Effects of major ozonated autohemotherapy in the treatment of dry age related macular degeneration: a randomized controlled clinical study. Int J Ophthalmol. 2012;5(6):708-13.

CHAVEZ PARDO, Iris et al . Ozone and antioxidants in (dry) macular degeneration related to age. AMC, Camagüey, v.12, n. 3, jun. 2008 .

Neroev VV, Zueva MV, Tsapenko IV, Khandzhian AT. [Effects of ozone therapy on the functional activity of the retina in patients with involutional central chorioretinal dystrophy]. Vestn Oftalmol. 2003 Nov-Dec;119(6):18-21. 

Russian.Neroev VV, Sarygina OI, Zueva MV, Tsapenko IV, Egorova EN. [Impact of ozone therapy on the electrophysiological parameters of the retina in patients operated on for its rhegmatogenous detachment].Vestn Oftalmol. 2007 Sep-Oct;123(5):33-6

Russian.Berson EL, Remulla JF, Rosner B, Sandberg MA, Weigel-DiFranco C. Evaluation of patients with retinitis pigmentosa receiving electric stimulation, ozonated blood, and ocular surgery in Cuba. Arch Ophthalmol. 1996 May;114(5):560-3.

Copello, M., Eguía, F., Menéndez, S., & Menéndez, N. (2003). Ozone therapy in patients with retinitis pigmentosa. OZONE SCIENCE & ENGINEERING,25(3), 223-232.

E. C. Díaz, L.Borrego1, S. Menéndez2, L. R. Borrego3, R. A. Borrego3. I. Ozone therapy in different ophthalmologic diseases. (Abstract from 2nd International Symposia on Ozone Applications, Cuba).

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